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?-Silyl Amides: Effective Bifunctional Lynchpins for Type I Anion Relay Chemistry.

ABSTRACT: Lynchpins comprising ?-silyl amides have been validated for type I anion relay chemistry (ARC) to permit ready access to ?-ketoamides. Importantly, the ARC protocol can be run at ambient temperature without the need of additional reagents to trigger the [1,4] Brook rearrangement.

SUBMITTER: Montgomery TD

PROVIDER: S-EPMC5712993 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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α-Silyl Amides: Effective Bifunctional Lynchpins for Type I Anion Relay Chemistry.

Montgomery Thomas D TD Smith Amos B AB

Organic letters 20171109 22

Lynchpins comprising α-silyl amides have been validated for type I anion relay chemistry (ARC) to permit ready access to γ-ketoamides. Importantly, the ARC protocol can be run at ambient temperature without the need of additional reagents to trigger the [1,4] Brook rearrangement. ...[more]

PMID: 29120188

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