Ontology highlight
ABSTRACT:
SUBMITTER: Zeng B
PROVIDER: S-EPMC5714946 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Nature communications 20171204 1
Impaired albumin reabsorption by proximal tubular epithelial cells (PTECs) has been highlighted in diabetic nephropathy (DN), but little is known about the underlying molecular mechanisms. Here we find that ORAI1-3, are preferentially expressed in PTECs and downregulated in patients with DN. Hyperglycemia or blockade of insulin signaling reduces the expression of ORAI1-3. Inhibition of ORAI channels by BTP2 and diethylstilbestrol or silencing of ORAI expression impairs albumin uptake. Transgenic ...[more]