Nonmuscle myosin II is a critical regulator of clathrin-mediated endocytosis.
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ABSTRACT:
SUBMITTER: Chandrasekar I
PROVIDER: S-EPMC3975594 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
Nonmuscle myosin II is a critical regulator of clathrin-mediated endocytosis.
Chandrasekar Indra I Goeckeler Zoe M ZM Turney Stephen G SG Wang Peter P Wysolmerski Robert B RB Adelstein Robert S RS Bridgman Paul C PC
Traffic (Copenhagen, Denmark) 20140212 4
Variable requirements for actin during clathrin-mediated endocytosis (CME) may be related to regional or cellular differences in membrane tension. To compensate, local regulation of force generation may be needed to facilitate membrane curving and vesicle budding. Force generation is assumed to occur primarily through actin polymerization. Here we examine the role of myosin II using loss of function experiments. Our results indicate that myosin II acts on cortical actin scaffolds primarily in th ...[more]
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