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Synthesis of Polycyclic Imidazolidinones via Amine Redox-Annulation.

ABSTRACT: ?-Ketoamides undergo redox-annulations with cyclic secondary amines, such as 1,2,3,4-tetrahydroisoquinoline, pyrrolidine, piperidine, and morpholine. Catalytic amounts of benzoic acid significantly accelerate these transformations. This approach provides polycyclic imidazolidinone derivatives in typically good yields.

SUBMITTER: Zhu Z

PROVIDER: S-EPMC5715285 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Synthesis of Polycyclic Imidazolidinones via Amine Redox-Annulation.

Zhu Zhengbo Z Lv Xin X Anesini Jason E JE Seidel Daniel D

Organic letters 20171116 23

α-Ketoamides undergo redox-annulations with cyclic secondary amines, such as 1,2,3,4-tetrahydroisoquinoline, pyrrolidine, piperidine, and morpholine. Catalytic amounts of benzoic acid significantly accelerate these transformations. This approach provides polycyclic imidazolidinone derivatives in typically good yields. ...[more]

PMID: 29144764

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