Ontology highlight
ABSTRACT:
SUBMITTER: Dai Q
PROVIDER: S-EPMC5716208 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Nucleic acids research 20171201 21
Transposable elements (TEs) compose about 40% of the murine genome. Retrotransposition of active TEs such as LINE-1 (L1) tremendously impacts genetic diversification and genome stability. Therefore, transcription and transposition activities of retrotransposons are tightly controlled. Here, we show that the Krüppel-like zinc finger protein Zfp281 directly binds and suppresses a subset of retrotransposons, including the active young L1 repeat elements, in mouse embryonic stem (ES) cells. In addit ...[more]