Ontology highlight
ABSTRACT:
SUBMITTER: He J
PROVIDER: S-EPMC6318327 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
He Jiangping J Fu Xiuling X Zhang Meng M He Fangfang F Li Wenjuan W Abdul Mazid Md MM Zhou Jianguo J Sun Li L Chang Chen C Li Yuhao Y Liu He H Wu Kaixin K Babarinde Isaac A IA Zhuang Qiang Q Loh Yuin-Han YH Chen Jiekai J Esteban Miguel A MA Hutchins Andrew P AP
Nature communications 20190103 1
The majority of mammalian genomes are devoted to transposable elements (TEs). Whilst TEs are increasingly recognized for their important biological functions, they are a potential danger to genomic stability and are carefully regulated by the epigenetic system. However, the full complexity of this regulatory system is not understood. Here, using mouse embryonic stem cells, we show that TEs are suppressed by heterochromatic marks like H3K9me3, and are also labelled by all major types of chromatin ...[more]