Ontology highlight
ABSTRACT:
SUBMITTER: Todd CD
PROVIDER: S-EPMC6544436 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
eLife 20190423
Transposable elements (TEs) are thought to have helped establish gene regulatory networks. Both the embryonic and extraembryonic lineages of the early mouse embryo have seemingly co-opted TEs as enhancers, but there is little evidence that they play significant roles in gene regulation. Here we tested a set of long terminal repeat TE families for roles as enhancers in mouse embryonic and trophoblast stem cells. Epigenomic and transcriptomic data suggested that a large number of TEs helped to est ...[more]