Ontology highlight
ABSTRACT:
SUBMITTER: Maio G
PROVIDER: S-EPMC5716488 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
ChemistrySelect 20170306 7
Nucleic acid aptamers (NAAs) are short synthetic DNA or RNA molecules that specifically fold into distinct three-dimensional structures able to specifically recognize a target. While NAAs show unprecedented promise in a variety of applications, including sensing, therapeutics and diagnostics, one major limitation involves the lack of stability towards omnipresent nucleases. Therefore, we herein report a systematic truncation and incorporation of 2'-O-methyl bases to a DNA aptamer, which results ...[more]