Ontology highlight
ABSTRACT:
SUBMITTER: de Boer DV
PROVIDER: S-EPMC5716703 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
de Boer D Vicky DV Martens-de Kemp Sanne R SR Buijze Marijke M Stigter-van Walsum Marijke M Bloemena Elisabeth E Dietrich Ralf R Leemans C René CR van Beusechem Victor W VW Braakhuis Boudewijn J M BJM Brakenhoff Ruud H RH
Oncotarget 20170516 58
Head and neck squamous cell carcinomas (HNSCC) and local relapses thereof develop in preneoplastic fields in the mucosal linings of the upper aerodigestive tract. These fields are characterized by tumor-associated genetic changes, are frequently dysplastic and occasionally macroscopically visible. Currently, no adequate treatment options exist to prevent tumor development. Array-based screening with a panel of tumor-lethal small interfering RNAs (siRNAs) identified <i>Polo-like kinase 1</i> (<i> ...[more]