Ontology highlight
ABSTRACT:
SUBMITTER: Crocetti L
PROVIDER: S-EPMC5718994 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Crocetti Letizia L Bartolucci Gianluca G Cilibrizzi Agostino A Giovannoni Maria Paola MP Guerrini Gabriella G Iacovone Antonella A Menicatti Marta M Schepetkin Igor A IA Khlebnikov Andrei I AI Quinn Mark T MT Vergelli Claudia C
Chemistry Central journal 20171206 1
Human neutrophil elastase (HNE) is a potent serine protease belonging to the chymotrypsin family and is involved in a variety of pathologies affecting the respiratory system. Thus, compounds able to inhibit HNE proteolytic activity could represent effective therapeutics. We present here the synthesis of new thiazol-2-(3H)-ones as an elaboration of potent HNE inhibitors with an isoxazol-5-(2H)-one scaffold that we recently identified. Two-dimensional NMR spectroscopic techniques and tandem mass s ...[more]