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Genetic and Epigenetic Components of Aspirin-Exacerbated Respiratory Disease.

ABSTRACT: Aspirin-exacerbated respiratory disease (AERD) severity and its clinical phenotypes are characterized by genetic variation within pathways for arachidonic acid metabolism, inflammation, and immune responses. Epigenetic effects, including DNA methylation and histone protein modification, contribute to regulation of many genes that contribute to inflammatory states in AERD. The development of noninvasive, predictive clinical tests using data from genetic, epigenetic, pharmacogenetic, and biomarker studies will improve precision medicine efforts for AERD and asthma treatment.

SUBMITTER: Dahlin A

PROVIDER: S-EPMC5720138 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Genetic and Epigenetic Components of Aspirin-Exacerbated Respiratory Disease.

Dahlin Amber A Weiss Scott T ST

Immunology and allergy clinics of North America 20161101 4

Aspirin-exacerbated respiratory disease (AERD) severity and its clinical phenotypes are characterized by genetic variation within pathways for arachidonic acid metabolism, inflammation, and immune responses. Epigenetic effects, including DNA methylation and histone protein modification, contribute to regulation of many genes that contribute to inflammatory states in AERD. The development of noninvasive, predictive clinical tests using data from genetic, epigenetic, pharmacogenetic, and biomarker ...[more]

PMID: 27712769

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