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Aspirin-exacerbated respiratory disease: pathophysiological insights and clinical advances.

ABSTRACT: Asthma and chronic rhinosinusitis are heterogeneous airway diseases of the lower and upper airways, respectively. Molecular and cellular studies indicate that these diseases can be categorized into unique endotypes, which have therapeutic implications. One such endotype is aspirin-exacerbated respiratory disease (AERD), which encompasses the triad of asthma, aspirin (or nonsteroidal anti-inflammatory drug) hypersensitivity, and nasal polyposis. AERD has unique pathophysiological features that distinguish it from aspirin-tolerant asthma and other forms of chronic rhinosinusitis. This review details molecular and cellular features of AERD and highlights current and future therapies that are based on these insights.

SUBMITTER: Steinke JW

PROVIDER: S-EPMC4790533 | biostudies-other | 2016

REPOSITORIES: biostudies-other

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Aspirin-exacerbated respiratory disease: pathophysiological insights and clinical advances.

Steinke John W JW Wilson Jeff M JM

Journal of asthma and allergy 20160310

Asthma and chronic rhinosinusitis are heterogeneous airway diseases of the lower and upper airways, respectively. Molecular and cellular studies indicate that these diseases can be categorized into unique endotypes, which have therapeutic implications. One such endotype is aspirin-exacerbated respiratory disease (AERD), which encompasses the triad of asthma, aspirin (or nonsteroidal anti-inflammatory drug) hypersensitivity, and nasal polyposis. AERD has unique pathophysiological features that di ...[more]

PMID: 27022293

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