Dataset Information

Associations between inflammatory gene polymorphisms (TNF-? 308G/A, TNF-? 238G/A, TNF-? 252A/G, TGF-?1 29T/C, IL-6 174G/C and IL-10 1082A/G) and susceptibility to osteosarcoma: a meta-analysis and literature review.

ABSTRACT: Associations between inflammatory gene polymorphisms (TNF-? 308G/A, TNF-? 238G/A, TNF-? 252A/G, TGF-?1 29T/C, IL-6 174G/C and IL-10 1082A/G) and osteosarcoma (OS) risk remain unclear. We conducted a systematic search to retrieve studies that investigated associations between inflammatory gene polymorphisms and OS risk. Nine studies that met the inclusion criteria were finally recruited in this meta-analysis. Overall, there was a significant association between TNF-? 308G/A, IL-10 1082A/G and OS risk, while there was no significant association between TNF-? 238G/A, TNF-? 252A/G and IL-6 174G/C and OS risk. Our subgroup analysis showed a significant association between IL-6 174G/C and IL-10 1082A/G and OS risk in Asians, while no such significant correlation was observed with TNF-? 308G/A, TNF-? 238G/A, TNF-? 252A/G and TGF-?1 29T/C polymorphisms. In Caucasians, there was a significant association between TNF-? 238G/A and the decreased incidence of OS. In conclusion, inflammatory gene polymorphisms play a key role in the occurrence and progression of OS. IL-6 174G/C polymorphism was obviously associated with OS risk in Asians, while TNF-? 238G/A polymorphism seemed to be associated with the decreased susceptibility to OS in Caucasians as Altman and Bland test indicated. Although controversial results were observed between IL-10 1082A/G and OS risk in Asians and Caucasians, it is difficult to make a definite conclusion about the role of IL-10 1082A/G polymorphism in the etiology of OS because our Altman and Bland test showed no good evidence to support a different effect in Asians and Caucasians.

SUBMITTER: Jiang Y

PROVIDER: S-EPMC5722585 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Publications

Associations between inflammatory gene polymorphisms (TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G, TGF-β1 29T/C, IL-6 174G/C and IL-10 1082A/G) and susceptibility to osteosarcoma: a meta-analysis and literature review.

Jiang Yanhua Y Wang Xiandi X Cheng Yi Y Peng Jun J Xiao Jiwei J Tang Dingbo D Yi Ying Y

Oncotarget 20170629 57

Associations between inflammatory gene polymorphisms (TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G, TGF-β1 29T/C, IL-6 174G/C and IL-10 1082A/G) and osteosarcoma (OS) risk remain unclear. We conducted a systematic search to retrieve studies that investigated associations between inflammatory gene polymorphisms and OS risk. Nine studies that met the inclusion criteria were finally recruited in this meta-analysis. Overall, there was a significant association between TNF-α 308G/A, IL-10 1082A/G and OS ...[more]

PMID: 29228633

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Project description:Background:Multiple studies have been carried out examining the association of tumor necrosis factor-? gene (TNF-?) promoter region polymorphisms with recurrent pregnancy loss (RPL) risk. However, the results remain controversial and incomplete. Hence, we performed a meta-analysis to evaluate the association of the TNF-? -308G>A and -238G>A polymorphisms with RPL risk. Materials and Methods:In this meta-analysis, a comprehensive search of PubMed, Web of Knowledge and EMBASE was performed to identify relevant studies published until December 1, 2017. The associations were assessed by odds ratio (OR) and its corresponding 95% confidence interval (CI). Results:A total of 29 case-control studies, comprising 20 studies on TNF-? -308G>A (3,461 cases and 3,895 controls) and nine studies on TNF-? -238G>A (2,589 cases and 2,664 controls), were included in the meta-analysis. Overall, we found TNF-? -308G>A to be associated with an increase in RPL risk under the homozygote (OR=1.716, 95% CI: 1.210-2.433, P=0.002) and the recessive (OR=1.554, 95% CI: 1.100-2.196, P=0.012) models. TNF-? -238G>A was also significantly associated with increased risk of RPL under the allele model (OR=1.554, 95% CI: 1.100-2.196, P=0.012). Stratified analysis revealed a more significant association between theTNF-? -308G>A polymorphism and increased RPL risk in Asians under the homozygote (OR=2.190, 95% CI: 1.465-3.274, P?0.001), the dominant (OR=1.642, 95% CI: 1.269-2.125, P?0.001) and the recessive (OR=1.456, 95% CI: 1.039-2.040, P=0.029) models, but not in Caucasians. A non-significant association was, however, identified between TNF-? -238G>A and RPL risk based on ethnicity. Moreover, TNF-? -308G>A and -238G>A polymorphisms were significantly associated with increased risk of RPL in high quality studies and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) subgroups. Conclusion:The present meta-analysis demonstrates that TNF-? -308G>A and -238G>A polymorphisms are associated with an increased risk of RPL.

Dataset Information

Associations between inflammatory gene polymorphisms (TNF-? 308G/A, TNF-? 238G/A, TNF-? 252A/G, TGF-?1 29T/C, IL-6 174G/C and IL-10 1082A/G) and susceptibility to osteosarcoma: a meta-analysis and literature review.

Publications

Associations between inflammatory gene polymorphisms (TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G, TGF-β1 29T/C, IL-6 174G/C and IL-10 1082A/G) and susceptibility to osteosarcoma: a meta-analysis and literature review.

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