Ontology highlight
ABSTRACT:
SUBMITTER: Yan T
PROVIDER: S-EPMC5722651 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Science advances 20171208 12
<i>N</i>-alkyl amino acids find widespread application as highly valuable, renewable building blocks. However, traditional synthesis methodologies to obtain these suffer from serious limitations, providing a major challenge to develop sustainable alternatives. We report the first powerful catalytic strategy for the direct N-alkylation of unprotected α-amino acids with alcohols. This method is highly selective, produces water as the only side product leading to a simple purification procedure, an ...[more]