Heterogeneous ¹ H and ¹³ C Parahydrogen-Induced Polarization of Acetate and Pyruvate Esters.

ABSTRACT: Magnetic resonance imaging of [1-¹³ C]hyperpolarized carboxylates (most notably, [1-¹³ C]pyruvate) allows one to visualize abnormal metabolism in tumors and other pathologies. Herein, we investigate the efficiency of ¹ H and ¹³ C hyperpolarization of acetate and pyruvate esters with ethyl, propyl and allyl alcoholic moieties using heterogeneous hydrogenation of corresponding vinyl, allyl and propargyl precursors in isotopically unlabeled and 1-¹³ C-enriched forms with parahydrogen over Rh/TiO₂ catalysts in methanol-d₄ and in D₂ O. The maximum obtained ¹ H polarization was 0.6±0.2 % (for propyl acetate in CD₃ OD), while the highest ¹³ C polarization was 0.10±0.03 % (for e

SUBMITTER: Salnikov OG 

PROVIDER: S-EPMC8249325 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature