Ontology highlight
ABSTRACT:
SUBMITTER: Somech R
PROVIDER: S-EPMC5726601 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Somech Raz R Lev Atar A Lee Yu Nee YN Simon Amos J AJ Barel Ortal O Schiby Ginette G Avivi Camila C Barshack Iris I Rhodes Michele M Yin Jiejing J Wang Minshi M Yang Yibin Y Rhodes Jennifer J Marcus Nufar N Garty Ben-Zion BZ Stein Jerry J Amariglio Ninette N Rechavi Gideon G Wiest David L DL Zhang Yong Y
Journal of immunology (Baltimore, Md. : 1950) 20171110 12
Regulation of the actin cytoskeleton is crucial for normal development and function of the immune system, as evidenced by the severe immune abnormalities exhibited by patients bearing inactivating mutations in the Wiskott-Aldrich syndrome protein (WASP), a key regulator of actin dynamics. WASP exerts its effects on actin dynamics through a multisubunit complex termed Arp2/3. Despite the critical role played by Arp2/3 as an effector of WASP-mediated control over actin polymerization, mutations in ...[more]