Ontology highlight
ABSTRACT:
SUBMITTER: Petrie Aronin CE
PROVIDER: S-EPMC5726790 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Petrie Aronin Caren E CE Zhao Yun M YM Yoon Justine S JS Morgan Nicole Y NY Prüstel Thorsten T Germain Ronald N RN Meier-Schellersheim Martin M
Immunity 20171101 5
Chemoattractant-mediated recruitment of hematopoietic cells to sites of pathogen growth or tissue damage is critical to host defense and organ homeostasis. Chemotaxis is typically considered to rely on spatial sensing, with cells following concentration gradients as long as these are present. Utilizing a microfluidic approach, we found that stable gradients of intermediate chemokines (CCL19 and CXCL12) failed to promote persistent directional migration of dendritic cells or neutrophils. Instead, ...[more]