Ontology highlight
ABSTRACT:
SUBMITTER: Trost BM
PROVIDER: S-EPMC5726859 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Trost Barry M BM Masters James T JT Le Vaillant Franck F Lumb Jean-Philip JP
The Journal of organic chemistry 20161013 20
A unique intramolecular Pd-catalyzed alkyne-alkyne coupling is presented. This transformation generates a strained, 1,3-bridged, macrocyclic enyne. The process was readily executed on gram scale, and the structure of the product was elucidated via X-ray crystallographic analysis. A mechanistic rationale for the observed chemoselectivity is provided. ...[more]