Ontology highlight
ABSTRACT:
SUBMITTER: Tanno T
PROVIDER: S-EPMC5728314 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Tanno Toshihiko T Zhang Peng P Lazarski Christopher A CA Liu Yang Y Zheng Pan P
Blood advances 20170622 15
The efficacy of traditional chemotherapy is limited by its toxicity, especially with regard to hematopoiesis. Here we show that miR-26a plays a critical role in protecting mice against chemotherapy-induced myeloid suppression by targeting a proapoptotic protein (Bak1) in hematopoietic stem/progenitor cells (HSPCs). Because c-Kit is expressed at high levels in HSPCs, we designed a microRNA-aptamer chimera that contains miR-26a mimic and c-Kit-targeting aptamer and successfully delivered miR-26a i ...[more]