Ontology highlight
ABSTRACT:
SUBMITTER: Niina T
PROVIDER: S-EPMC5728581 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
PLoS computational biology 20171201 12
While nucleosome positioning on eukaryotic genome play important roles for genetic regulation, molecular mechanisms of nucleosome positioning and sliding along DNA are not well understood. Here we investigated thermally-activated spontaneous nucleosome sliding mechanisms developing and applying a coarse-grained molecular simulation method that incorporates both long-range electrostatic and short-range hydrogen-bond interactions between histone octamer and DNA. The simulations revealed two distin ...[more]