Dataset Information

Dose-response effects of aerobic exercise on body composition among colon cancer survivors: a randomised controlled trial.

ABSTRACT:

Background

Physical activity is associated with a lower risk of disease recurrence among colon cancer survivors. Excess visceral adipose tissue is associated with a higher risk of disease recurrence among colon cancer survivors. The pathways through which physical activity may alter disease outcomes are unknown, but may be mediated by changes in visceral adipose tissue.

Methods

Thirty-nine stage I-III colon cancer survivors were randomised to one of three groups: usual-care control, 150 min wk^-1 of aerobic exercise (low dose) and 300 min wk^-1 of aerobic exercise (high dose) for 6 months. The prespecified key body composition outcome was visceral adipose tissue quantified using dual energy X-ray absorptiometry.

Results

Exercise reduced visceral adipose tissue in dose-response fashion (P_trend=0.008). Compared with the control group, the low- and high-dose exercise groups lost 9.5 cm² (95% CI: -22.4, 3.5) and 13.6 cm² (95% CI: -27.0, -0.1) in visceral adipose tissue, respectively. Each 60 min wk^-1 increase in exercise predicted a 2.7 cm² (95% CI: -5.4, -0.1) reduction in visceral adipose tissue.

Conclusions

Aerobic exercise reduces visceral adipose tissue in dose-response fashion among patients with stage I-III colon cancer. Visceral adipose tissue may be a mechanism through which exercise reduces the risk of disease recurrence among colon cancer survivors.

SUBMITTER: Brown JC

PROVIDER: S-EPMC5729439 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Publications

Dose-response effects of aerobic exercise on body composition among colon cancer survivors: a randomised controlled trial.

Brown Justin C JC Zemel Babette S BS Troxel Andrea B AB Rickels Michael R MR Damjanov Nevena N Ky Bonnie B Rhim Andrew D AD Rustgi Anil K AK Courneya Kerry S KS Schmitz Kathryn H KH

British journal of cancer 20170921 11

<h4>Background</h4>Physical activity is associated with a lower risk of disease recurrence among colon cancer survivors. Excess visceral adipose tissue is associated with a higher risk of disease recurrence among colon cancer survivors. The pathways through which physical activity may alter disease outcomes are unknown, but may be mediated by changes in visceral adipose tissue.<h4>Methods</h4>Thirty-nine stage I-III colon cancer survivors were randomised to one of three groups: usual-care contro ...[more]

PMID: 28934762

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Project description:Despite the clear health benefits of exercise, exercised-induced weight loss is often less than expected. The term 'exercise energy compensation' is used to define the amount of weight loss below what is expected for the amount of exercise energy expenditure. We examined the dose-response effects of exercise volume on energy compensation in postmenopausal women.Data from Alberta Physical Activity and Breast Cancer Prevention (ALPHA) and Breast Cancer and Exercise Trial in Alberta (BETA) were combined for the present analysis. The ALPHA and BETA trials were two-centred, two-armed, 12-month randomized controlled trials. The ALPHA trial included 160 participants randomized to 225 min per week of aerobic exercise, and the BETA trial randomized 200 participants to each 150 and 300 min per week of aerobic exercise. All participants were aged 50-74 years, moderately inactive (<90 min per week of exercise), had no previous cancer diagnosis and a body mass index between 22 and 40 kg m-2. Energy compensation was based on changes in body composition (dual-energy X-ray absorptiometry scan) and estimated exercise energy expenditure from completed exercise volume. Associations between Δenergy intake, ΔVO2peak and Δphysical activity time with energy compensation were assessed.No differences in energy compensation were noted between interventions. However, there were large inter-individual differences in energy compensation between participants; 9.4% experienced body composition changes that were greater than expected based on exercise energy expenditure, 64% experienced some degree of energy compensation and 26.6% experienced weight gain based on exercise energy expenditure. Increases in VO2peak were associated with reductions in energy compensation (β=-3.44 ml kg-1 min-1, 95% confidence interval for β=-4.71 to -2.17 ml kg-1 min-1; P=0.0001).Large inter-individual differences in energy compensation were noted, despite no differences between activity doses. In addition, increases in VO2peak were associated with lower energy compensation. Future studies are needed to identify behavioral and metabolic factors that may contribute to this large inter-individual variability in energy compensation.

Dataset Information

Dose-response effects of aerobic exercise on body composition among colon cancer survivors: a randomised controlled trial.

Background

Methods

Results

Conclusions

Publications

Dose-response effects of aerobic exercise on body composition among colon cancer survivors: a randomised controlled trial.

Similar Datasets

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