Dataset Information

Dose-response effects of exercise on insulin among colon cancer survivors.

ABSTRACT: Physical activity is associated with a lower risk of disease recurrence among colon cancer survivors. The pathways through which physical activity may alter disease outcomes are unknown, but may include changes in metabolic growth factors, such as insulin. Between January 2015 and August 2015, 39 stage I-III colon cancer survivors were randomized to one of the three groups: usual care control, 150?min/week of aerobic exercise (low-dose) and 300?min/week of aerobic exercise (high-dose) for six months. The pre-specified key metabolic growth factor outcome was fasting insulin. Insulin resistance was quantified using the homeostatic model assessment. Mean age was 56.5?±?10.0 years, 51% had stage III disease, 72% were treated with chemotherapy and the mean time since finishing treatment was 10.9?±?6.1 months. Over six months, the low-dose group completed 141.5?±?9.9?min/week of aerobic exercise, and the high-dose group completed 247.2?±?10.7?min/week of aerobic exercise. Fasting insulin concentrations decreased 7.4?±?9.4?pmol/L in the control group, 28.0?±?8.3?pmol/L in the low-dose group and 20.7?±?9.3?pmol/L in the high-dose group (nonlinear Ptrend?=?0.042). Insulin resistance decreased 0.11?±?0.20 in the control group, 0.63?±?0.17 in the low-dose group and 0.43?±?0.19 in the high-dose group (nonlinear Ptrend?=?0.012). Aerobic exercise reduces insulin concentrations and insulin resistance among patients with stage I-III colon cancer. Prescribing 150?min/week of aerobic exercise may be sufficient for reducing insulin concentrations and insulin resistance, which may partially mediate the relationship between physical activity and colon cancer prognosis.

SUBMITTER: Brown JC

PROVIDER: S-EPMC5736434 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Dose-response effects of exercise on insulin among colon cancer survivors.

Brown Justin C JC Rickels Michael R MR Troxel Andrea B AB Zemel Babette S BS Damjanov Nevena N Ky Bonnie B Rhim Andrew D AD Rustgi Anil K AK Courneya Kerry S KS Schmitz Kathryn H KH

Endocrine-related cancer 20171010 1

Physical activity is associated with a lower risk of disease recurrence among colon cancer survivors. The pathways through which physical activity may alter disease outcomes are unknown, but may include changes in metabolic growth factors, such as insulin. Between January 2015 and August 2015, 39 stage I-III colon cancer survivors were randomized to one of the three groups: usual care control, 150 min/week of aerobic exercise (low-dose) and 300 min/week of aerobic exercise (high-dose) for six mo ...[more]

PMID: 29018055

Similar Datasets

Project description:PurposeThis study aimed to examine mediators of fatigue response to an exercise intervention for breast cancer survivors in a pilot randomized controlled trial.MethodsPostmenopausal breast cancer survivors (n = 46; ≤stage 2), off primary treatment, and reporting fatigue and/or sleep dysfunction were randomized to a 3-month exercise intervention (160 min·wk of moderate-intensity aerobic walking, twice weekly resistance training with resistance bands) or control group. Six discussion group sessions provided behavioral support to improve adherence. Fatigue, serum cytokines, accelerometer physical activity, cardiorespiratory fitness, sleep dysfunction, and psychosocial factors were assessed at baseline and 3 months.ResultsThe exercise intervention effect sizes for fatigue were as follows: fatigue intensity d = 0.30 (P = 0.34), interference d = -0.38 (P = 0.22), and general fatigue d = -0.49 (P = 0.13). Using the Freedman-Schatzkin difference-in-coefficients tests, increase in fatigue intensity was significantly mediated by interleukin 6 (IL-6) (82%), IL-10 (94%), IL-6/IL-10 (49%), and tumor necrosis factor-α (TNF-α):IL-10 (78%) with reduced sleep dysfunction increasing the relationship between intervention and fatigue intensity rather than mediating intervention effects (-88%). Decrease in fatigue interference was mediated by sleep dysfunction (35%), whereas IL-10 and pro-anti-inflammatory cytokine ratios increased the relationship between intervention and interference (-25% to -40%). The reduction in general fatigue was significantly mediated by minutes of physical activity (76%), sleep dysfunction (45%), and physical activity enjoyment (40%), with IL-10 (-40%) and IL-6/IL-10 (-11%) increasing the intervention-fatigue relationship. In the intervention group, higher baseline fatigue, anxiety, depression, and perceived exercise barrier interference predicted a greater decline in fatigue interference and/or general fatigue during the intervention.ConclusionsBiobehavioral factors mediated and enhanced intervention effects on fatigue, whereas psychosocial factors predicted fatigue response. Further study is warranted to confirm our results and to improve understanding of relationships that mediate and strengthen the intervention-fatigue association.

Dataset Information

Dose-response effects of exercise on insulin among colon cancer survivors.

Publications

Dose-response effects of exercise on insulin among colon cancer survivors.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets