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A randomized dose-response trial of aerobic exercise and health-related quality of life in colon cancer survivors.

ABSTRACT: OBJECTIVE:To examine the dose-response effects of aerobic exercise on health-related quality of life (HRQoL) among colon cancer survivors. METHODS:Thirty-nine stage I to III colon cancer survivors were randomized to 1 of 3 groups: usual-care control, 150 min·wk-1 of aerobic exercise (low-dose) and 300 min·wk-1 of aerobic exercise (high-dose) for 6 months. HRQoL outcomes included the Short Form (SF)-36 physical and mental component summary, Functional Assessment of Cancer Therapy-Colorectal, Pittsburgh Sleep Quality Index, Fear of Cancer Recurrence Inventory, Fatigue Symptom Inventory, and North Central Cancer Treatment Group bowel function questionnaire, assessed at baseline and post intervention. The primary hypothesis was that exercise would improve HRQoL outcomes in a dose-response fashion, such that high-dose aerobic exercise would yield the largest improvements in HRQoL outcomes. RESULTS:Over 6 months, the low-dose group completed 141 ± 10 min·wk-1 of aerobic exercise, and the high-dose group completed 247 ± 11 min·wk-1 of aerobic exercise. Over 6 months, exercise improved the physical component summary score of the SF-36 (Ptrend = 0.002), the Functional Assessment of Cancer Therapy-Colorectal (Ptrend = 0.025), the Pittsburgh Sleep Quality Index (Ptrend = 0.049), and the Fatigue Symptom Inventory (Ptrend = 0.045) in a dose-response fashion. Between-group standardized mean difference effects sizes for the above-described findings were small to moderate in magnitude (0.35-0.75). No dose-response effects were observed for the mental component summary score of the SF-36, the Fear of Cancer Recurrence Inventory, or bowel function. CONCLUSION:Higher doses of aerobic exercise, up to 300 min·wk-1 , improve multiple HRQoL outcomes among stage I to III colon cancer survivors. These findings provide evidence that aerobic exercise may provide multiple health benefits for colon cancer survivors.

SUBMITTER: Brown JC

PROVIDER: S-EPMC5895514 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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A randomized dose-response trial of aerobic exercise and health-related quality of life in colon cancer survivors.

Brown Justin C JC Damjanov Nevena N Courneya Kerry S KS Troxel Andrea B AB Zemel Babette S BS Rickels Michael R MR Ky Bonnie B Rhim Andrew D AD Rustgi Anil K AK Schmitz Kathryn H KH

Psycho-oncology 20180220 4

<h4>Objective</h4>To examine the dose-response effects of aerobic exercise on health-related quality of life (HRQoL) among colon cancer survivors.<h4>Methods</h4>Thirty-nine stage I to III colon cancer survivors were randomized to 1 of 3 groups: usual-care control, 150 min·wk<sup>-1</sup> of aerobic exercise (low-dose) and 300 min·wk<sup>-1</sup> of aerobic exercise (high-dose) for 6 months. HRQoL outcomes included the Short Form (SF)-36 physical and mental component summary, Functional Assessme ...[more]

PMID: 29388275

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Project description:BACKGROUND:Exercise is an effective strategy to improve quality of life and physical fitness in breast cancer survivors; however, few studies have focused on the early survivorship period, minorities, physically inactive and obese women, or tested a combined exercise program and measured bone health. Here, we report the effects of a 16-week aerobic and resistance exercise intervention on patient-reported outcomes, physical fitness, and bone health in ethnically diverse, physically inactive, overweight or obese breast cancer survivors. METHODS:One hundred breast cancer survivors within 6 months of completing adjuvant treatment were assessed at baseline, post-intervention, and 3-month follow-up (exercise group only) for physical fitness, bone mineral density, serum concentrations of bone biomarkers, and quality of life. The exercise intervention consisted of moderate-vigorous (65-85% heart rate maximum) aerobic and resistance exercise thrice weekly for 16 weeks. Differences in mean changes for outcomes were evaluated using mixed-model repeated measure analysis. RESULTS:At post-intervention, the exercise group was superior to usual care for quality of life (between group difference: 14.7, 95% CI: 18.2, 9.7; p?<?0.001), fatigue (p?<?0.001), depression (p?<?0.001), estimated VO2max (p?<?0.001), muscular strength (p?<?0.001), osteocalcin (p?=?0.01), and BSAP (p?=?0.001). At 3-month follow-up, all patient-reported outcomes and physical fitness variables remained significantly improved compared to baseline in the exercise group (p?<?0.01). CONCLUSIONS:A 16-week combined aerobic and resistance exercise program designed to address metabolic syndrome in ethnically-diverse overweight or obese breast cancer survivors also significantly improved quality of life and physical fitness. Our findings further support the inclusion of supervised clinical exercise programs into breast cancer treatment and care. TRIAL REGISTRATION:This trial is registered on ClinicalTrials.gov: NCT01140282 as of June 9, 2010.

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A randomized dose-response trial of aerobic exercise and health-related quality of life in colon cancer survivors.

Publications

A randomized dose-response trial of aerobic exercise and health-related quality of life in colon cancer survivors.

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