Ontology highlight
ABSTRACT:
SUBMITTER: Rohn TT
PROVIDER: S-EPMC5734658 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
International journal of neurology and neurotherapy 20170731 2
One of the most important genetic risk factors for late-onset Alzheimer's Disease (AD) is harboring the <i>ApoE4</i> allele. Much is known regarding the functions of the ApoE4 protein including cholesterol transport in the CNS and a critical role in clearing beta-amyloid deposits in the AD brain. However, recent studies demonstrating the nuclear localization suggest a novel function beyond the classical known actions of ApoE4. The purpose of the current review is to examine how this secreted pro ...[more]