Ontology highlight
ABSTRACT:
SUBMITTER: Anantharam P
PROVIDER: S-EPMC5734662 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Anantharam Poojya P Whitley Elizabeth M EM Mahama Belinda B Kim Dong-Suk DS Sarkar Souvarish S Santana Cristina C Chan Adriano A Kanthasamy Anumantha G AG Kanthasamy Arthi A Boss Gerry R GR Rumbeiha Wilson K WK
Annals of the New York Academy of Sciences 20171101 1
Hydrogen sulfide (H<sub>2</sub> S) is a highly neurotoxic gas. Acute exposure can lead to neurological sequelae among survivors. A drug for treating neurological sequelae in survivors of acute H<sub>2</sub> S intoxication is needed. Using a novel mouse model we evaluated the efficacy of cobinamide (Cob) for increasing survival of, and reducing neurological sequalae in, mice exposed to sublethal doses of H<sub>2</sub> S. There were two objectives: (1) to determine the dose-response efficacy of Co ...[more]