Ontology highlight
ABSTRACT:
SUBMITTER: Izzi V
PROVIDER: S-EPMC5735295 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Izzi Valerio V Lakkala Juho J Devarajan Raman R Savolainen Eeva-Riitta ER Koistinen Pirjo P Heljasvaara Ritva R Pihlajaniemi Taina T
Leukemia research reports 20171213
Relapse of acute myeloid leukemia (AML) is still dramatically frequent, imposing the need for early markers to quantify such risk. Recent evidence point to a prominent role for extracellular matrix (ECM) in AML, but its prognostic value has not yet been investigated. Here we have investigated whether the expression of a 15-ECM gene signature could be applied to clinical AML research evaluating a retrospective cohort of 61 AML patients and 12 healthy donors. Results show that patients whose ECM s ...[more]