Ontology highlight
ABSTRACT:
SUBMITTER: Prattichizzo F
PROVIDER: S-EPMC5735298 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Prattichizzo Francesco F De Nigris Valeria V Mancuso Elettra E Spiga Rosangela R Giuliani Angelica A Matacchione Giulia G Lazzarini Raffaella R Marcheselli Fiorella F Recchioni Rina R Testa Roberto R La Sala Lucia L Rippo Maria Rita MR Procopio Antonio Domenico AD Olivieri Fabiola F Ceriello Antonio A
Redox biology 20171206
Diabetic status is characterized by chronic low-grade inflammation and an increased burden of senescent cells. Recently, the senescence-associated secretory phenotype (SASP) has been suggested as a possible source of inflammatory factors in obesity-induced type 2 diabetes. However, while senescence is a known consequence of hyperglycaemia, evidences of SASP as a result of the glycaemic insult are missing. In addition, few data are available regarding which cell types are the main SASP-spreading ...[more]