Unknown

Dataset Information

0

Recent advances in the use of ZFN-mediated gene editing for human gene therapy.


ABSTRACT: Targeted genome editing with programmable nucleases has revolutionized biomedical research. The ability to make site-specific modifications to the human genome, has invoked a paradigm shift in gene therapy. Using gene editing technologies, the sequence in the human genome can now be precisely engineered to achieve a therapeutic effect. Zinc finger nucleases (ZFNs) were the first programmable nucleases designed to target and cleave custom sites. This article summarizes the advances in the use of ZFN-mediated gene editing for human gene therapy and discusses the challenges associated with translating this gene editing technology into clinical use.

SUBMITTER: Chandrasegaran S 

PROVIDER: S-EPMC5736148 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7676468 | biostudies-literature
| S-EPMC8306493 | biostudies-literature
| S-EPMC3821724 | biostudies-literature
| S-EPMC6319315 | biostudies-literature
| S-EPMC7544018 | biostudies-literature
| S-EPMC8562678 | biostudies-literature
| S-EPMC9319960 | biostudies-literature
| S-EPMC7686539 | biostudies-literature
| S-EPMC8431496 | biostudies-literature
| S-EPMC4870579 | biostudies-literature