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Polymer-mediated gene therapy: Recent advances and merging of delivery techniques.

ABSTRACT: The ability to safely and precisely deliver genetic materials to target sites in complex biological environments is vital to the success of gene therapy. Numerous viral and nonviral vectors have been developed and evaluated for their safety and efficacy. This study will feature progress in synthetic polymers as nonviral vectors, which benefit from their chemical versatility, biocompatibility, and ability to carry both therapeutic cargo and targeting moieties. The combination of synthetic gene carrying constructs with advanced delivery techniques promises new therapeutic options for treating and curing genetic disorders. This article is characterized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies.

SUBMITTER: Salameh JW

PROVIDER: S-EPMC7676468 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Polymer-mediated gene therapy: Recent advances and merging of delivery techniques.

Salameh Janelle W JW Zhou Le L Ward Sarah M SM Santa Chalarca Cristiam F CF Emrick Todd T Figueiredo Marxa L ML

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 20191202 2

The ability to safely and precisely deliver genetic materials to target sites in complex biological environments is vital to the success of gene therapy. Numerous viral and nonviral vectors have been developed and evaluated for their safety and efficacy. This study will feature progress in synthetic polymers as nonviral vectors, which benefit from their chemical versatility, biocompatibility, and ability to carry both therapeutic cargo and targeting moieties. The combination of synthetic gene ca ...[more]

PMID: 31793237

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