Ontology highlight
ABSTRACT:
SUBMITTER: Hiwarkar P
PROVIDER: S-EPMC5737134 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Hiwarkar Prashant P Hubank Mike M Qasim Waseem W Chiesa Robert R Gilmour Kimberly C KC Saudemont Aurore A Amrolia Persis J PJ Veys Paul P
Blood advances 20171102 24
Omission of in vivo T-cell depletion promotes rapid, thymic-independent CD4<sup>+</sup>-biased T-cell recovery after cord blood transplant. This enhanced T-cell reconstitution differs from that seen after stem cell transplant from other stem cell sources, but the mechanism is not known. Here, we demonstrate that the transcription profile of naive CD4<sup>+</sup> T cells from cord blood and that of lymphocytes reconstituting after cord blood transplantation is similar to the transcription profile ...[more]