Ontology highlight
ABSTRACT:
SUBMITTER: Wieczor M
PROVIDER: S-EPMC5737604 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Nucleic acids research 20170701 13
Target search as performed by DNA-binding proteins is a complex process, in which multiple factors contribute to both thermodynamic discrimination of the target sequence from overwhelmingly abundant off-target sites and kinetic acceleration of dynamic sequence interrogation. TRF1, the protein that binds to telomeric tandem repeats, faces an intriguing variant of the search problem where target sites are clustered within short fragments of chromosomal DNA. In this study, we use extensive (>0.5 ms ...[more]