Ontology highlight
ABSTRACT:
SUBMITTER: Long J
PROVIDER: S-EPMC6108177 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20171030 12
During meiotic prophase, the meiosis-specific telomere-binding protein TERB1 regulates chromosome movement required for homologous pairing and recombination by interacting with the telomeric shelterin subunit TRF1. Here, we report the crystal structure of the TRF1-binding motif of human TERB1 in complex with the TRFH domain of TRF1. Notably, specific disruption of the TERB1-TRF1 interaction by a point mutation in the mouse Terb1 gene results in infertility only in males. We find that this mutati ...[more]