Pharmacokinetics of a Long-Acting Nanoformulated Dolutegravir Prodrug in Rhesus Macaques.
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ABSTRACT:
SUBMITTER: McMillan J
PROVIDER: S-EPMC5740312 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
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Pharmacokinetics of a Long-Acting Nanoformulated Dolutegravir Prodrug in Rhesus Macaques.
McMillan JoEllyn J Szlachetka Adam A Slack Lara L Sillman Brady B Lamberty Benjamin B Morsey Brenda B Callen Shannon S Gautam Nagsen N Alnouti Yazen Y Edagwa Benson B Gendelman Howard E HE Fox Howard S HS
Antimicrobial agents and chemotherapy 20171221 1
A nanoformulated myristoylated dolutegravir prodrug (NMDTG) was prepared using good laboratory practice protocols. Intramuscular injection of NMDTG (118 ± 8 mg/ml, 25.5 mg of DTG equivalents/kg of body weight) to three rhesus macaques led to plasma DTG levels of 86 ± 12 and 28 ± 1 ng/ml on days 35 and 91, respectively. The NMDTG platform showed no significant adverse events. Further modification may further extend the drug's apparent half-life for human use. ...[more]
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