Ontology highlight
ABSTRACT:
SUBMITTER: Sillman B
PROVIDER: S-EPMC5799307 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Sillman Brady B Bade Aditya N AN Dash Prasanta K PK Bhargavan Biju B Kocher Ted T Mathews Saumi S Su Hang H Kanmogne Georgette D GD Poluektova Larisa Y LY Gorantla Santhi S McMillan JoEllyn J Gautam Nagsen N Alnouti Yazen Y Edagwa Benson B Gendelman Howard E HE
Nature communications 20180206 1
Potent antiretroviral activities and a barrier to viral resistance characterize the human immunodeficiency virus type one (HIV-1) integrase strand transfer inhibitor dolutegravir (DTG). Herein, a long-acting parenteral DTG was created through chemical modification to improve treatment outcomes. A hydrophobic and lipophilic modified DTG prodrug is encapsulated into poloxamer nanoformulations (NMDTG) and characterized by size, shape, polydispersity, and stability. Retained intracytoplasmic NMDTG p ...[more]