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Antimicrobial Activities of Aztreonam-Avibactam and Comparator Agents against Contemporary (2016) Clinical Enterobacteriaceae Isolates.

ABSTRACT: A total of 10,451 contemporary (2016) Enterobacteriaceae isolates from 84 U.S. medical centers and 116 metallo-?-lactamase- and/or OXA-48-like-producing Enterobacteriaceae isolates from other countries were tested against aztreonam-avibactam and comparators. All U.S. isolates were inhibited at aztreonam-avibactam MICs of ?8 ?g/ml (MIC50, ?0.03 ?g/ml; MIC90, 0.12 ?g/ml), including Klebsiella pneumoniae carbapenemase-producing isolates (n = 102; MIC50, 0.25 ?g/ml; MIC90, 0.5 ?g/ml), multidrug-resistant isolates (n = 876; MIC50, 0.06 ?g/ml; MIC90, 0.25 ?g/ml), and extensively drug-resistant isolates (n = 111; MIC50, 0.12 ?g/ml; MIC90, 0.5 ?g/ml). The highest aztreonam-avibactam MIC value among ex-U.S. isolates was 4 ?g/ml.

SUBMITTER: Sader HS 

PROVIDER: S-EPMC5740368 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Antimicrobial Activities of Aztreonam-Avibactam and Comparator Agents against Contemporary (2016) Clinical Enterobacteriaceae Isolates.

Sader Helio S HS   Mendes Rodrigo E RE   Pfaller Michael A MA   Shortridge Dee D   Flamm Robert K RK   Castanheira Mariana M  

Antimicrobial agents and chemotherapy 20171221 1

A total of 10,451 contemporary (2016) <i>Enterobacteriaceae</i> isolates from 84 U.S. medical centers and 116 metallo-β-lactamase- and/or OXA-48-like-producing <i>Enterobacteriaceae</i> isolates from other countries were tested against aztreonam-avibactam and comparators. All U.S. isolates were inhibited at aztreonam-avibactam MICs of ≤8 μg/ml (MIC<sub>50</sub>, ≤0.03 μg/ml; MIC<sub>90</sub>, 0.12 μg/ml), including <i>Klebsiella pneumoniae</i> carbapenemase-producing isolates (<i>n</i> = 102; MI  ...[more]

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