Ontology highlight
ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC5741634 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Wang Chensu C Niederstrasser Hanspeter H Douglas Peter M PM Lin Rueyling R Jaramillo Juan J Li Yang Y Oswald Nathaniel W NW Zhou Anwu A McMillan Elizabeth A EA Mendiratta Saurabh S Wang Zhaohui Z Zhao Tian T Lin Zhiqaing Z Luo Min M Huang Gang G Brekken Rolf A RA Posner Bruce A BA MacMillan John B JB Gao Jinming J White Michael A MA
Nature communications 20171222 1
Drugs that mirror the cellular effects of starvation mimics are considered promising therapeutics for common metabolic disorders, such as obesity, liver steatosis, and for ageing. Starvation, or caloric restriction, is known to activate the transcription factor EB (TFEB), a master regulator of lipid metabolism and lysosomal biogenesis and function. Here, we report a nanotechnology-enabled high-throughput screen to identify small-molecule agonists of TFEB and discover three novel compounds that p ...[more]