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Neo-Aplysiatoxin A Isolated from Okinawan Cyanobacterium Moorea Producens.

ABSTRACT: A new aplysiatoxin derivative, neo-aplysiatoxin A (1), along with seven known compounds, neo-debromoaplysiatoxin A (2), dolastatin 3 (3), lyngbic acid (4), malyngamide M (5), hermitamide A (6), (-)-loliolide (7), and (+)-epiloliolide (8), was isolated from the Okinawan cyanobacterium Moorea producens. Their structures were elucidated on the basis of spectroscopic data, including high-resolution mass spectrometry and nuclear magnetic resonance. The compounds were evaluated for cytotoxic and diatom growth inhibition activities.

SUBMITTER: Kawaguchi M

PROVIDER: S-EPMC7037229 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Neo-Aplysiatoxin A Isolated from Okinawan Cyanobacterium Moorea Producens.

Kawaguchi Mioko M Satake Masayuki M Zhang Bo-Tao BT Xiao Yue-Yun YY Fukuoka Masayuki M Uchida Hajime H Nagai Hiroshi H

Molecules (Basel, Switzerland) 20200122 3

A new aplysiatoxin derivative, neo-aplysiatoxin A (1), along with seven known compounds, neo-debromoaplysiatoxin A (2), dolastatin 3 (3), lyngbic acid (4), malyngamide M (5), hermitamide A (6), (-)-loliolide (7), and (+)-epiloliolide (8), was isolated from the Okinawan cyanobacterium Moorea producens. Their structures were elucidated on the basis of spectroscopic data, including high-resolution mass spectrometry and nuclear magnetic ...[more]

PMID: 31978978

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