Ontology highlight
ABSTRACT:
SUBMITTER: Ding D
PROVIDER: S-EPMC7026180 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Ding Donglin D Huang Huixing H Li Quanfu Q Yu Wenbo W Wang Chenji C Ma Haijie H Wu Jiaxue J Dang Yongjun Y Yu Long L Jiang Wei W
Cell death discovery 20200122
Nuclear factor 90 (NF90), an RNA-binding protein, has been implicated in regulating interleukin-2 (IL-2) and the immune response. It was recently reported that NF90 is upregulated in hepatocellular carcinoma (HCC) tissues and promotes HCC proliferation through upregulating cyclin E1 at the posttranscription level. However, the regulation of NF90 in HCC remains unclear. We demonstrate here that cyclin-dependent kinase (CDK) 2 interacts with NF90 and phosphorylated it at serine382. Mechanistically ...[more]