DRD2: Bridging the Genome and Ingestive Behavior.
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ABSTRACT:
SUBMITTER: Sun X
PROVIDER: S-EPMC5745142 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
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DRD2: Bridging the Genome and Ingestive Behavior.
Sun Xue X Luquet Serge S Small Dana M DM
Trends in cognitive sciences 20170331 5
Recent work highlights the importance of genetic variants that influence brain structure and function in conferring risk for polygenic obesity. The neurotransmitter dopamine (DA) has a pivotal role in energy balance by integrating metabolic signals with circuits supporting cognitive, perceptual, and appetitive functions that guide feeding. It has also been established that diet and obesity alter DA signaling, leading to compulsive-like feeding and neurocognitive impairments. This raises the poss ...[more]
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