Ontology highlight
ABSTRACT:
SUBMITTER: Qiu Y
PROVIDER: S-EPMC5745159 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Qiu Yupeng Y Levendosky Robert F RF Chakravarthy Srinivas S Patel Ashok A Bowman Gregory D GD Myong Sua S
Molecular cell 20170921 1
Chromatin remodelers catalyze dynamic packaging of the genome by carrying out nucleosome assembly/disassembly, histone exchange, and nucleosome repositioning. Remodeling results in evenly spaced nucleosomes, which requires probing both sides of the nucleosome, yet the way remodelers organize sliding activity to achieve this task is not understood. Here, we show that the monomeric Chd1 remodeler shifts DNA back and forth by dynamically alternating between different segments of the nucleosome. Dur ...[more]