The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint.
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ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC5751143 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint.
Wang Qingshui Q Lin Wei W Tang Xiaoqiong X Li Suhuan S Guo Libin L Lin Yao Y Kwok Hang Fai HF
International journal of molecular sciences 20171127 12
Engagement of programmed death-ligand 1 (PD-L1) with its receptor programmed death 1 (PD-1) on T cells has been speculated to play a major role in suppressing the immune system, which helps tumor cells evade anti-tumor immunity. With the development of whole genome sequencing technologies, microRNAs have gained more attention as an important new layer of molecular regulation. Recent studies have revealed that altered expression of microRNAs play a pivotal role in immune checkpoint and various ce ...[more]
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