Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC6719739 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Wang Xiaobo X Sommerfeld Mark R MR Jahn-Hofmann Kerstin K Cai Bishuang B Filliol Aveline A Remotti Helen E HE Schwabe Robert F RF Kannt Aimo A Tabas Ira I
Hepatology communications 20190723 9
Nonalcoholic steatohepatitis (NASH) is emerging as a major public health issue and is associated with significant liver-related morbidity and mortality. At present, there are no approved drug therapies for NASH. The transcriptional coactivator with PDZ-binding motif (TAZ; encoded by WW domain-containing transcription regulator 1 [<i>WWTR1</i>]) is up-regulated in hepatocytes in NASH liver from humans and has been shown to causally promote inflammation and fibrosis in mouse models of NASH. As a p ...[more]