Ontology highlight
ABSTRACT:
SUBMITTER: Mlcochova P
PROVIDER: S-EPMC5753034 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Mlcochova Petra P Caswell Sarah J SJ Taylor Ian A IA Towers Greg J GJ Gupta Ravindra K RK
The EMBO journal 20171030 1
We report that DNA damage induced by topoisomerase inhibitors, including etoposide (ETO), results in a potent block to HIV-1 infection in human monocyte-derived macrophages (MDM). SAMHD1 suppresses viral reverse transcription (RT) through depletion of cellular dNTPs but is naturally switched off by phosphorylation in a subpopulation of MDM found in a G1-like state. We report that SAMHD1 was activated by dephosphorylation following ETO treatment, along with loss of expression of MCM2 and CDK1, an ...[more]