Ontology highlight
ABSTRACT:
SUBMITTER: Wu Y
PROVIDER: S-EPMC5754088 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Wu Yan Y Guo Xiao Peng XP Kanemoto Soshi S Maeoka Yujiro Y Saito Atsushi A Asada Rie R Matsuhisa Koji K Ohtake Yosuke Y Imaizumi Kazunori K Kaneko Masayuki M
PloS one 20180104 1
We identified 37 ubiquitin ligases containing RING-finger and transmembrane domains. Of these, we found that RNF183 is abundantly expressed in the kidney. RNF183 predominantly localizes to the endoplasmic reticulum (ER), Golgi, and lysosome. We identified Sec16A, which is involved in coat protein complex II vesicle formation, as an RNF183-interacting protein. RNF183 colocalized with Sec16A and interacted through the central conserved domain (CCD) of Sec16A. Although Sec16A is not a substrate for ...[more]