Ontology highlight
ABSTRACT:
SUBMITTER: Melero A
PROVIDER: S-EPMC6013297 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Melero Alejandro A Chiaruttini Nicolas N Karashima Takefumi T Riezman Isabelle I Funato Kouichi K Barlowe Charles C Riezman Howard H Roux Aurélien A
Current biology : CB 20180607 12
Coat protein complex II (COPII) proteins form vesicles from the endoplasmic reticulum to export cargo molecules to the Golgi apparatus. Among the many proteins involved in this process, Sec12 is a key regulator, functioning as the guanosine diphosphate (GDP) exchange factor for Sar1p, the small guanosine triphosphatase (GTPase) that initiates COPII assembly. Here we show that overexpression of phospholipase B3 in the thermosensitive sec12-4 mutant partially restores growth and protein transport ...[more]