Ontology highlight
ABSTRACT:
SUBMITTER: Gomez-Navarro N
PROVIDER: S-EPMC7711842 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Gomez-Navarro Natalia N Boulanger Jérôme J Miller Elizabeth A EA
Traffic (Copenhagen, Denmark) 20201020 11
The appropriate delivery of secretory proteins to the correct subcellular destination is an essential cellular process. In the endoplasmic reticulum (ER), secretory proteins are captured into COPII vesicles that generally exclude ER resident proteins and misfolded proteins. We previously characterized a collection of yeast mutants that fail to enforce this sorting stringency and improperly secrete the ER chaperone, Kar2 (Copic et al., Genetics 2009). Here, we used the emp24Δ mutant strain that s ...[more]