Abyssomicin 2 reactivates latent HIV-1 by a PKC- and HDAC-independent mechanism.
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ABSTRACT:
SUBMITTER: Leon B
PROVIDER: S-EPMC5755699 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Abyssomicin 2 reactivates latent HIV-1 by a PKC- and HDAC-independent mechanism.
León Brian B Navarro Gabriel G Dickey Bailey J BJ Stepan George G Tsai Angela A Jones Gregg S GS Morales Monica E ME Barnes Tiffany T Ahmadyar Shekeba S Tsiang Manuel M Geleziunas Romas R Cihlar Tomas T Pagratis Nikos N Tian Yang Y Yu Helen H Linington Roger G RG
Organic letters 20150105 2
Screening of a marine natural products library afforded three new analogues of the tetronic acid containing polyketide abyssomicin family and identified abyssomicin 2 as a selective reactivator of latent HIV virus. Examination of the mode of action of this new latent HIV reactivating agent demonstrated that it functions via a distinct mechanism compared to that of existing reactivating agents and is effective at reactivating latent virus in a subset of primary patient cell lines. ...[more]
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