Ontology highlight
ABSTRACT:
SUBMITTER: Dar D
PROVIDER: S-EPMC5756622 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Dar Daniel D Shamir Maya M Mellin J R JR Koutero Mikael M Stern-Ginossar Noam N Cossart Pascale P Sorek Rotem R
Science (New York, N.Y.) 20160401 6282
Riboswitches and attenuators are cis-regulatory RNA elements, most of which control bacterial gene expression via metabolite-mediated, premature transcription termination. We developed an unbiased experimental approach for genome-wide discovery of such ribo-regulators in bacteria. We also devised an experimental platform that quantitatively measures the in vivo activity of all such regulators in parallel and enables rapid screening for ribo-regulators that respond to metabolites of choice. Using ...[more]