Ontology highlight
ABSTRACT:
SUBMITTER: Xiao X
PROVIDER: S-EPMC5757249 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Xiao Xiangwei X Guo Ping P Shiota Chiyo C Zhang Ting T Coudriet Gina M GM Fischbach Shane S Prasadan Krishna K Fusco Joseph J Ramachandran Sabarinathan S Witkowski Piotr P Piganelli Jon D JD Gittes George K GK
Cell stem cell 20180101 1
Successful strategies for treating type 1 diabetes need to restore the function of pancreatic beta cells that are destroyed by the immune system and overcome further destruction of insulin-producing cells. Here, we infused adeno-associated virus carrying Pdx1 and MafA expression cassettes through the pancreatic duct to reprogram alpha cells into functional beta cells and normalized blood glucose in both beta cell-toxin-induced diabetic mice and in autoimmune non-obese diabetic (NOD) mice. The eu ...[more]