Ontology highlight
ABSTRACT:
SUBMITTER: Baker LA
PROVIDER: S-EPMC5758107 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Baker Lindsay A LA Sinnige Tessa T Schellenberger Pascale P de Keyzer Jeanine J Siebert C Alistair CA Driessen Arnold J M AJM Baldus Marc M Grünewald Kay K
Structure (London, England : 1993) 20171214 1
Membrane proteins remain challenging targets for structural biology, despite much effort, as their native environment is heterogeneous and complex. Most methods rely on detergents to extract membrane proteins from their native environment, but this removal can significantly alter the structure and function of these proteins. Here, we overcome these challenges with a hybrid method to study membrane proteins in their native membranes, combining high-resolution solid-state nuclear magnetic resonanc ...[more]